First, apply the best hydrophobic agent

1. Preparation of acid-resistant capsules

22.02kg of glycerin, 34.13kg of distilled water, 10kg of dimethyl silicone oil, 43.85kg of gelatin, dissolved under reduced pressure at 70-80 °C, and made into capsules by conventional methods. A mixture of formaldehyde/acetone (1/60) was sprayed onto the capsule to prepare. Due to the hydrophobic effect of the dimethyl silicone oil, the obtained capsule does not disintegrate in the acidic gastric juice for 2 hours, and dissolves in the alkaline intestinal solution for 200 to 620 seconds, and is stable to the enzyme and temperature, and has good mechanical strength.

2. Dyeing of sugar-coated tablets (glossing agent)

In the polishing operation, the Sichuan wax fine powder with 2% dimethicone is added to the coated glass tablet for polishing. The sugar coated tablet is brighter and more beautiful than the undiluted silicone oil. The moisture-proof effect ensures that the sugar-coated tablets are not discolored or mildewed during the storage period.

3, film coating material

It is used as a plasticizer for film coating materials. It utilizes the hydrophobicity and oxygen resistance of dimethyl silicone oil to isolate the core from the outside, is not affected by moisture, oxygen, etc. in the air, does not absorb moisture and deteriorates, and the coating layer is firm and smooth.

Second, the best condensing agent for water-soluble drop pills

The behavior of the droppings of the dropping pills in the condensing agent may be spread, formed into droplets and mixed. Generally, a liquid having a small surface tension is placed on a surface of a liquid having a large surface tension, and spreading occurs, and on the contrary, droplets are easily formed. Dimethicone is the lowest surface energy condensing agent in common water-soluble drop pellets (liquid paraffin 0.035 N/m, vegetable oil 0.035 N/m, dimethicone 0.021 N/m).

There are many different types of dimethicone models. The temperature and the different types of dimethicone can be adjusted to adjust the molding and precipitation speed of the droplets in the condensing agent to achieve the best process conditions and quality conditions. There is a hidden danger of polluting petrochemical toxic substances and water-based dropping pills, which are not guaranteed by liquid paraffin and vegetable oil.

In particular, S-40 (polyoxyethylene monostearate) and poloxamer-based pellets must use dimethyl silicone oil as the condensate, and liquid paraffin should not be used as the condensate. Silicone oil can increase the dissolution of water-insoluble active drugs, which is beneficial to the absorption of drugs; poloxamer can not use liquid paraffin as condensate because of its hygroscopicity. (Dimethyl silicone oil periodic treatment technology in the production of dropping pills; because the price of dimethicone is relatively expensive, it should be recycled as much as possible in the production. The dimethicone that has been used will be mixed with foreign matter. One of the most common foreign materials is produced when the dropping pills are prepared. The broken pellets can be removed by filtration, static precipitation or centrifugation; otherwise, the common foreign matter is water. When dimethicone is used as a condensing agent, the dropping pills may be dissolved, deformed or even condensed. Hard, the method of removing moisture from the simethicone is to freeze the soul-moisture dimethyl silicone oil at -4 ° C, remove the water after it has condensed into ice, and quickly filter it to remove it.

3. The only effective antistatic agent in the production of micropowder and pellets

The pellet or pellet is fluidized in the fluidized bed. When the material passes through the spray area, the mist of the clothing material is sprayed on the surface thereof, and is adhered, spread, dried and adhered to form a small film. After repeated spraying, the film gradually expands, and finally forms a continuous overall coat layer to achieve the purpose of coating. In order to ensure safe operation and complete dispersion of the materials, the powder is not allowed to stick to the dough, and the antistatic agent should be added when the powder is sprayed.

Dimethicone is currently the only pharmaceutical excipient with antistatic effect, and the amount of antistatic agent used is 0.1% by weight of the powder.

Fourth, used as a lubricant in solid preparations

Lubricant refers to the general term for the excipients that are added to the material to be pressed before being pressed to have or increase the fluidity, anti-adhesion and lubricity to facilitate the tableting process. According to the action mechanism of the lubricant, it is divided into three types; the lubricant refers to an auxiliary material capable of reducing the friction between the particles or the tablet and the die.

After the tablet die is cleaned, a layer of dimethicone can also be applied to solve the problem of sticking of some varieties.

1. Sustained release aspirin tablets

Take aspirin powder 1000g (crystal diameter 0.1770mm), ethoxyethyl cellulose (containing 12% ethoxy 12%) 70g, dissolve in 300ml (1:1) toluene-dichloromethane solution and dimethicone containing 30g The toluene solution, 400 g of starch, 300 g of glyceryl palmitate hard fatty acid ester, 50 g of talc, and 100 g of microcrystalline cellulose are obtained by a conventional method.

2, compound paracetamol capsules

The aspirin pellets were heated to 50 ° C, coated with a 1:1 copolymer of methacrylic acid and methacrylate and 0.045% AF emulsion (antifoam), dried in a boiling dry bed at 37.8 ° C for more than 24 h, then Weigh 52.144g, add 0.203g of sodium lauryl sulfate, 41.45g of paracetamol, 0.363g of dimethicone, 0.145g of polyoxyethylene dehydrated monooleate, and mix it evenly. The capsule weighed 700 mg each containing 325 mg each of aspirin and paracetamol.

3, ibuprofen sustained release tablets

Take ibuprofen 58.25%, lactose 14.50%, calcium hydrogen phosphate 12.60%, glyceryl behenate 11.65%, magnesium stearate 1.0%, talc + silicone oil (4:1) 2.0% conventionally made into tablets.

Methyl Low Hydrogen silicone oil ,pls check MY 203